The role of formins as down-stream effector molecules of nephrocystins (P18)

• Subject Area: Cell Biology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Nephronophthisis is an autosomal recessive disorder caused by mutations in almost 20 different genes. Most gene products localize to the cilium, and there, a defective ciliary function appears to cause this hereditary disease. Preliminary data indicate that severel nephronophthisis-associated gene products influence the actin cytoskeleton through interaction with formins. It will now be clarified whether and how these interactions with actin-modifying proteins can influence the diverse cellular programs that appear to be controlled by nephrocystins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Gerd Walz