Enantioselective Synthesis and Functionalization of Heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane and Related Cage Compounds

• Applicant: Professor Dr. Manuel Alcarazo
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation ; Inorganic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393120588

Along this research project different approaches dealing with the efficient synthesis and the regio- and enantioselective (poly)fuctionalization of heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane (HCTD) are proposed. Given the structural relationship between HCTD and adamantane derived cages, in particular diamantane, and the number of applications that these compounds have found in areas as diverse as medicinal chemistry or material science; it is envisaged that functionalized HTDC might also be interesting building blocks for the modification of drugs or the design of mechanochemical devices. In case of success, this research project will open an expeditious entry to these structures. Finally, we plan to preliminary test their practical utility.

• DFG Programme: Research Grants