Characterization of ribosomal stalling sequences and their recognition by the RQT quality control factors

• Applicant: Professor Dr. Roland Beckmann
• Subject Area: Structural Biology ; Biochemistry
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394323889

Final Report Abstract

No abstract available

Publications

• Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways. EMBO J. 2019 38
  Ikeuchi, K., Tesina, P., Matsuo, Y., Sugiyama, T., Cheng, J., Saeki, Y., Tanaka, K., Becker, T., Beckmann, R., and Inada, T.
  
• Structural and mutational analysis of the ribosome-arresting human XBP1u. eLife 2019; 8:e46267
  Shanmuganathan, V., Schiller, N. Magoulopoulou, A.,Cheng, J., Braunger, K., Cymer, F., Berninghausen, O., Beatrix, B., Kohno, K., von Heijne, G., Beckmann, R.
  
• Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis. Nature 2019 570, 538–542
  Su,T., Izawa T., Thoms, M., Yamashita, Y, Cheng, J., Berninghausen, O., Hartl, U.F., Inada, T., Neupert, W., Beckmann, R.
  
• Structure of the 80S ribosome–Xrn1 nuclease complex. Nat. Struct. Mol. Biol. 2019. 26(4):p. 275-280
  Tesina, P., Heckel, E., Cheng, J., Fromont-Racine, M., Buschauer, R., Kater, L., Beatrix, B., Berninghausen, O., Jacquier, A., Becker, T., Beckmann, R.
  
• Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts. EMBO J. 2020 39, e103365
  Tesina, P., Lessen, L.N., Buschauer, R., Cheng, J., Wu, C.C., Berninghausen, O., Buskirk, A.R., Becker, T., Beckmann, R., and Green, R.
  
• RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat Struct Mol Biol 2020 27, 323-332
  Matsuo, Y., Tesina, P., Nakajima, S., Mizuno, M., Endo, A., Buschauer, R., Cheng, J., Shounai, O., Ikeuchi, K., Saeki, Y., Becker, T., Beckmann, R. and Inada T.
  
• Structural basis of L-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide. Nucleic Acids Res 2021 49, 9539-9547
  Su, T., Kudva, R., Becker, T., Buschauer, R., Komar, T., Berninghausen, O., von Heijne, G., Cheng, J., and Beckmann, R.