Dynamic regulation of synaptic calcium channels by neurexins (A03)

• Subject Area: Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

We investigate neurotransmission by studying how voltage-gated calcium channels are regulated by various neurexin (Nrxn) variants. Using mostly live cell imaging techniques and genetically modified mice, we predominantly monitor the effect of Nrxn variants on Ca2+ influx and release of synaptic vesicles as well as of dense-core vesicle from cultured hippocampal neurons, in order to better understand the mechanisms of this important process.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Markus Missler