Membrane platforms in regulated secretion from endothelial cells (A04)

• Subject Area: Cell Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

This project addresses how membrane platforms rich in PA and PI(4,5)P2 serve as Weibel-Palade body (WPB) tethering and/or fusion sites, which proteins are required to establish these platforms and how they link to the WPB. In particular, we analyze the contribution of different Rab proteins and Rab effector functions in the late steps of WPB exocytosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Volker Gerke