Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (A11+)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 229838028

We will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs (A1, A2, A3) in combination with biological ligands and sensor molecules (A10). The resulting macromolecular ligands will be analyzed for their modulation of different proteins such as the N-D1 interface of p97 (B2), 14-3-3 protein (B4), Survivin and Taspase1 (B5), mitotic regulators (B6) and Ndc80-microtubule interactions (B7).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1093: Supramolecular Chemistry on Proteins
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professorin Dr. Laura Hartmann