Deciphering the role of DM-sensitive and DM-resistant antigens in immune responses after ASCT (A01)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

DM-sensitive antigens are promising targets for selective GvL effects without GvHD. We isolated CD4+ T-cell clones targeting these antigens in mismatched HLA-DP, recognizing primary AML blasts while sparing non-hematopoietic cells. For clinical translation, we aim to develop scalable, GMP-grade T-cell products and assess their GvL and GvHD potential using AML blasts and patient-derived organoids. Preliminary post-ASCT data suggest a link between T-cell responses to DM-resistant antigens and GvHD. To elucidate this relationship, we will longitudinally track T-cell clones targeting DM-sensitive /-resistant antigens in ASCT patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Privatdozentin Dr. Anita Kremer, until 12/2025; Professor Dr. Andreas Mackensen, since 1/2026; Dr. Hannah Reimann, since 1/2022