Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in GvHD (B08)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

Regulatory T cells (Treg) perform two distinct functions: they maintain self-tolerance and support tissue-repair and organ homeostasis by differentiation into specialized tissue-Treg cells. To harness the tissue-repair functions of these cells for preventing or treating GvHD after ASCT, we will combine in vitro organoid and in vivo mouse experiments with mathematical modelling with the aim of engineering 'tissue smart' Treg cells for the therapy of GvHD. We will translate these findings to human Treg cells to establish novel Treg cell therapy formats.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Markus Feuerer; Professor Dr. Frederik Graw, since 1/2026