Project Details
Projekt
Regulation of tissue-resident myeloid cells controling acute and chronic GvHD (B09)
Subject Area
Hematology, Oncology
Immunology
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634
We identified a population of specialized regulatory antigen presenting cells, termed tissue-resident macrophages, in the gastro-intestinal tract that protects from acute GvHD. These intestinal macrophages control pathogenic T cells via PD-L1. By employing preclinical mouse models for GvHD and GvL and analyses of allo-HSCT patient samples, we will interrogate the molecular cues that drive immunoprotective antigen presenting cell differentiation and function. We will explore these cells in tissues of GvHD such as the intestinal tract and skin and compare them with tissues, where GvHD typically does not manifest. Finally, potential prophylactic and therapeutic strategies will be tested.
DFG Programme
CRC/Transregios
Subproject of
TRR 221:
Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
Applicant Institution
Universität Regensburg
Project Heads
Professor Dr. Andreas Beilhack; Dr. Mercedes Gomez de Agüero, since 1/2022
