Project Details
Projekt
Modifying the vitamin K system to halt/regress cardiovascular calcification in CKD patients (C01)
Subject Area
Nephrology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Patients with CKD display massively increased cardiovascular calcifications, which contribute to their higher cardiovascular mortality risk. Increased cardiovascular calcification in CKD is triggered, among others, by functional vitamin K deficiency. We identified nutritional compounds that interact with the vitamin K system in vascular calcification processes. We hypothesize that the functional vitamin K deficiency contributes to the uremic toxins load in CKD and that it can be treated to such a degree that we can maximize clinical cardiovascular benefit. Therefore, this project aims to develop a novel nutritional approach in form of a “kidney diet” to reduce cardiovascular calcification in CKD patients.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Jürgen Floege, until 7/2023; Dr. Nadine Kaesler, since 8/2023; Professor Dr. Rafael Kramann, since 8/2023
