Modulation of the dysregulated alternative complement pathway in CKD (C07)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Patients with CKD display alterations in the coagulation system resulting in an increased thrombotic and bleeding risk, which causes an augmented cardiovascular risk in these patients. We recently demonstrated the incorporation of complement C3 into fibrin clots, leading to a prothrombotic clot structure with thinner fibrin fibers and resistance to fibrinolysis. Also, the alternative complement pathway plays an important role in complement activation. Based on novel findings, this project aims to modify the dysregulated alternative complement pathway in CKD with the aim to reduce thrombotic risk in these patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professorin Dr. Katharina Marx-Schütt