Project Details
Projekt
Modulation of metabolic and functional changes in uremic cardiomyopathy (M03)
Subject Area
Cardiology, Angiology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
CKD induces processes of accelerated aging in the heart, termed uremic cardiomyopathy (UC), leading to cellular senescence, degeneration and fibrosis by yet incompletely understood mechanisms. This project will provide further mechanistic insights into altered cardiac metabolism in CKD and will also reveal the role of PYY in CKD and CKD-associated CVD. Translation of these findings into clinical practice could lead to innovative approaches such as PYY receptor modulation to reduce cardiovascular morbidity and mortality in CKD patients.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Michael Lehrke, until 12/2025; Professor Dr. Nikolaus Albert Helmut Marx
