Mass spectrometry to identify, quantify and localize novel regulators of pathological processes underlying CKD-associated CVD (S03)

• Subject Area: Biochemistry
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We have demonstrated that mass spectrometry is a powerful beyond the state-of-the-art technique that, when combined with chromatographic separation and functional assays, enables the identification of novel regulators and underlying mechanisms and regulators of pathological processes. Furthermore, mass spectrometry is an ideal method to study post-translational modifications (PTMs) of proteins and peptides, with a broad spectrum of PTMs identified in the first funding period to be involved in the pathology of CKD-associated CVD. By using a combination of chromatography, mass spectrometry and MALDI imaging, this service project will continue to provide a critical core proteomic facility to the partners within this consortium to gain deeper insights into the pathology of CKD-associated CVD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Joachim Jankowski; Professorin Dr. Vera Jankowski, Ph.D.