Harnessing hepatic tolerance mechanisms for antigen-specific treatment of autoimmune and allergic diseases (T01)

• Subject Area: Gastroenterology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

We have developed a nanoparticle-based method for selective delivery of antigen peptides to tolerance-inducing liver cells. In a mouse model of multiple sclerosis, this method provided exceptional therapeutic efficacy. Here we aim at the translation of this approach into a widely applicable antigen-specific therapeutic platform for important autoimmune and allergic diseases. As an essential step towards clinical application, we seek to obtain proof-of-concept in relevant preclinical models for type 1 diabetes, rheumatoid arthritis, cholangitis, or food allergy.

• DFG Programme: Collaborative Research Centres (Transfer Project)
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Heads: Dr. Antonella Carambia; Professor Dr. Jörg Heeren; Professor Dr. Johannes Herkel