Hyaluronic acid-based bioink platform with multi-functional crosslinkers for the controlled differentiation of mesenchymal stem cells (A02)

• Subject Area: Biomaterials
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

Hyaluronic acid (HA) represents a major component of the human extracellular matrix, however, so far highly versatile HA-based materials for biofabrication are lacking. The overall aim of this project is to develop a HA-based bioink platform utilizing multi-functional crosslinkers (PEG, modified biopolymers) that enables the controlled differentiation of mesenchymal stem cells. The modification with peptides and growth factors as well as the processing into gradient materials will further promote the development of coherent tissues within the printed 3D constructs. For the long term, this work aims to generate bioinks for the development of clinically relevant tissue models.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the fundamentals of biofabrication towards functional tissue models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Torsten Blunk; Dr. Jörg Teßmar