TRR 225:  From the Fundamentals of Biofabrication towards Functional Tissue Models

• Subject Area: Materials Science and Engineering ; Biology ; Mechanical and Industrial Engineering ; Medicine ; Physics
• Term: since 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

No abstract available

• DFG Programme: CRC/Transregios
• International Connection: USA

Current projects

• A01 - Alginate-based bioinks with tailorable microstructural properties for controlled cell-material-interactions (Project Heads Boccaccini, Aldo ;  Fabry, Ben )
• A02 - Tunable hyaluronic acid-based bioink platform for controlled differentiation of mesenchymal stem cells (Project Heads Blunk, Torsten ;  Teßmar, Jörg )
• B03 - Biofabrication of perfusable skeletal muscle tissue and cellular biomechanic analysis (Project Heads Boccaccini, Aldo ;  Cavalcanti-Adam, Elisabetta Ada ;  Döpper, Frank ;  Hansmann, Jan ;  Salehi-Müller, Ph.D., Sahar )
• B04 - From 3D bioprinting to functional and adaptive vascular tissue constructs (Project Heads Ergün, Süleyman ;  Groll, Jürgen ;  Kleefeldt, Florian )
• B05 - Membrane engineering as a tool to control the behavior of mesenchymal stroma cells in biofabrication processes (Project Heads Ebert, Regina ;  Nuhn, Ph.D., Lutz ;  Seibel, Jürgen )
• B06 - Reporter bioinks and particles for online detection of protease activity (Project Heads Detsch, Rainer ;  Leiske, Meike ;  Lühmann, Tessa Charlotte ;  Thievessen, Ingo )
• B07 - Characterization and modeling of mechanical stresses in cellular aggregates during bioprinting (Project Heads Albrecht, Krystyna ;  Fery, Andreas ;  Gekle, Stephan ;  Groll, Jürgen ;  Papastavrou, Georg )
• B09 - Biofabricated gradients to study melanoma tumor progression in defined microenvironments (Project Heads Budday, Silvia ;  Jüngst, Tomasz ;  Schmid, Rafael )
• B10 - Bio-printed fiber-reinforced spinal cord tissue models for the study of neurodegenerative diseases (Project Heads Lang, Gregor ;  Schäfer, Natascha )
• B11 - Tubular supply for 3D tissue based on shape-changing polymers and recombinant spider silk (Project Heads Ionov, Leonid ;  Scheibel, Thomas )
• C01 - Biofabrication of heart substitute tissues based on bioinks from spider silk proteins (Project Heads Engel, Felix B. ;  Scheibel, Thomas )
• C02 - Biofabrication of 3D models for functional investigation of stromal parameters influencing the migration of breast cancer cells (Project Heads Blunk, Torsten ;  Fabry, Ben ;  Wittmann, Katharina )
• C03 - Analysis of tumor dormancy and progression in biofabricated vascularized 3D models (Project Heads Arkudas, Andreas ;  Bosserhoff, Anja-Katrin ;  Kengelbach-Weigand, Annika )
• C04 - Biofabrication of a cellularized and by the AV-loop vascularized tissue con-tainer for the transplantation of cells producing therapeutic proteins (Project Heads Horch, Raymund E. ;  Promny, Theresa ;  Wajant, Harald Günther )
• C05 - Neuronal network modulation by glioblastoma and breast tumors bioprinted in a 3D brain-like matrix (Project Heads Dalton, Paul ;  Detsch, Rainer ;  Strick, Reiner ;  Villmann, Carmen )
• C06 - Biofabrication strategies for modelling kidney compartments and diseases (Project Heads Ahmad, Ph.D., Taufiq ;  Müller-Deile, Janina )
• C07 - Endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models (Project Heads Appelt-Menzel, Antje ;  Cicha, Ph.D., Iwona ;  Ryma, Matthias )
• Z01 - Centrals tasks of the Collaborative Research Centre (Project Head Groll, Jürgen )
• Z02 - Multidimensional imaging to assess post-fabrication maturation of 3D-printed bio-fabricates (Project Heads Friedrich, Oliver ;  Heinze, Katrin G. ;  Weiss, Matthias )

Completed projects

• A03 - Thermo-gelling poly(2-oxazolin) based hydrogels with temporal mechanical control (Project Heads Luxenhofer, Robert ;  Lühmann, Tessa Charlotte )
• A04 - Expansion of the biofabrication window using 2.5D scaffolds made from (AB)n-segmented copolymers (Project Heads Dalton, Paul ;  Schmidt, Hans-Werner )
• A06 - Cell-loaded microgels as mechanical protection and controlled microenvironment for cells in bioinks (Project Heads Förster, Stephan ;  Groll, Jürgen )
• A07 - Influence of anisotropic fiber-reinforcement on cell behavior and printability of bioinks (Project Heads Lang, Gregor ;  Schubert, Dirk W. ;  Schäfer, Natascha )
• A08 - Vascular supply for 3D tissue based on shape-changing polymers and recombinant spider silk (Project Heads Ionov, Leonid ;  Scheibel, Thomas )
• B02 - Endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models. (Project Heads Cicha, Ph.D., Iwona ;  Groll, Jürgen )
• B08 - Time-resolved biophotonics approach cellular signaling, cell-matrix interactions and matrix remodeling mechanisms in biofabricated constructs (Project Heads Beilhack, Andreas ;  Friedrich, Oliver )
• Z03 - Fluorescent reporter cells for live-cell imaging in biofabrication (Project Head Bosserhoff, Anja-Katrin )

• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Co-Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg; Universität Bayreuth
• Spokesperson: Professor Dr. Jürgen Groll