Neuronal network modulation by glioblastoma and breast tumors bioprinted in a 3D brain-like matrix (C05(B01))

• Subject Area: Biophysics ; Biomaterials ; Developmental Neurobiology ; Molecular Biology and Physiology of Neurons and Glial Cells ; Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

Glioblastoma multiforme and breast tumors disseminating into and throughout the brain are the most devastating human brain tumors. The overall aim of this project is to employ a brain-like ECM as hydrogel, which allows functional network formation of human neurons, astrocytes, microglia, and GBM cells and is suitable to study the efficiency of chemotherapeutic agents. Precise spatial and temporal architecture is enabled by bioprinting of different cell types but also spheroids using Drop on demand and extrusion printing.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the Fundamentals of Biofabrication towards Functional Tissue Models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Paul Dalton, until 12/2021; Dr.-Ing. Rainer Detsch, since 6/2025; Professor Dr. Reiner Strick; Professorin Dr. Carmen Villmann