Expansion of the biofabrication window using 2.5D scaffolds made from (AB)n-segmented copolymers (A04+)

• Subject Area: Biomaterials
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

The aim of the project is the expansion of the biofabrication window of bioinks. By using 2.5D scaf-folds - a structurally stable substrate - for the bioprinting process a better precision and reproducibil-ity of the bioink depostion can be achieved. For this purpose, new (AB)n-segmented copolymers with hydrophilic soft segments and supramolecular hard segments are developed, which can be pro-cessed by Melt Electrospinning Writing. By selective swelling with biological media hydrogel scaf-folds are formed covering a wide range of Young’s Moduli and enabling different cellular interactions. Until today, this cannot be realized with conventional biofabrication processes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the fundamentals of biofabrication towards functional tissue models
• International Connection: USA
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Paul Dalton, until 3/2021; Professor Dr. Hans-Werner Schmidt