Endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models.
(B02)
Subject Area
Biomaterials
Term
from 2018 to 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133
The aim of this project is biofabrication of perfusable and endothelialized microvascular networks, which will be produced by MEW of sacrificial thermoresponsive polyoxazolines. Particular focus will be placed on adapting the network geometry and the surrounding cell-containing hydrogels to tissue-specific requirements of B and C projects and to the design of appropriate microscopy-compliant bioreactors. Besides, extensive investigations of endothelial function in the fabricated tissue models are planned, including angiogenesis, interactions with circulating cells, barrier function and regulation of physiological processes in the hydrogel-contained cells.
DFG Programme
CRC/Transregios
