Biofabrication of perfusable skeletal muscle tissue and cellular biomechanic analysis (B03)

• Subject Area: Biomaterials ; Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

This project aims to develop different multifunctional bioinks with ion-releasing, electrically conductive, oxygenating, reactive oxygen species (ROS) scavenging, and antioxidant properties for the bioprinting of perfusable skeletal muscle tissue. The microchannels-integrated muscle constructs will be fabricated using bioinks that provide key biochemical, biophysical, and biomechanical cues to the muscle and endothelial cells. The mechanobiological analysis enables us to understand how cell-bioink mechanical interactions influence muscle cell behavior.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the Fundamentals of Biofabrication towards Functional Tissue Models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr.-Ing. Aldo Boccaccini; Professorin Dr. Elisabetta Ada Cavalcanti-Adam, since 1/2026; Professor Dr.-Ing. Frank Döpper, since 1/2022; Professor Dr.-Ing. Jan Hansmann, until 12/2021; Professorin Sahar Salehi-Müller, Ph.D.