Project Details
Projekt
Biofabrication of 3D models for functional investigation of stromal parameters influencing the migration of breast cancer cells (C02)
Subject Area
Biomaterials
Biophysics
Biophysics
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133
This project aims at the biofabrication of complex tumor-stroma models to specifically study the migration of breast cancer cells as a function of stromal parameters. Using bioinks with controllable physicochemical properties, the influence of structure, mechanics, and matrix remodeling on cancer cell migration is systematically characterized. In spatially defined compartment models, we analyze in depth how neighboring stromal cells from adipose tissue influence directed single cell and collective migration of breast cancer cells. These bioprinted 3D models will enable a profound understanding of the dynamic tumor-stroma interplay and its role in tumor progression.
DFG Programme
CRC/Transregios
Applicant Institution
Julius-Maximilians-Universität Würzburg
Project Heads
Professor Dr. Torsten Blunk, since 5/2018; Professor Dr. Ben Fabry; Dr. Katharina Wittmann, until 5/2018
