Cellular mechanisms of drug resistance evolution (A01)

• Subject Area: Evolutionary Cell and Developmental Biology (Zoology)
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

The overarching goal of this project is to predict key aspects of resistance evolution from readily accessible measurements of antibiotic responses. We will (1) synthetically manipulate antibiotic dose-response characteristics, (2) build and parameterize mathematical models to predict the rate and repeatability of resistance evolution, and (3) test theoretical predictions in quantitative evolution experiments.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1310: Predictability in Evolution
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Tobias Bollenbach