Predicting evolutionary shifts of cell metabolism (A03)

• Subject Area: Evolutionary Cell and Developmental Biology (Zoology)
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

We will predict evolutionary changes of bacterial metabolism in response to drug action or environmental challenges. Predictions will be grounded on fitness models that treat external challenge and intrinsic evolutionary response as correlated perturbations of the cell’s metabolic network. The project has two intertwined parts: pedicting mechanisms of antibiotic resistance evolution (in collaboration with project A1), and predicting metabolic differentiation of bacterial lineages in the ecosystem of the mouse gut (in collaboration with project A6).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1310: Predictability in Evolution
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Michael Lässig