pH-switchable shark-derived single domain antibodies for biomedical applications

• Applicant: Professor Dr. Harald Kolmar
• Subject Area: Biochemistry
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 398463564

• Final Report Year: 2022

No abstract available

Publications

• Dual Function pH Responsive Bispecific Antibodies for Tumor Targeting and Antigen Depletion in Plasma. Frontiers Immunol (2019)
  Bogen, Jan P.; Hinz, Steffen C.; Grzeschik, Julius; Ebenig, Aileen; Krah, Simon; Zielonka, Stefan & Kolmar, Harald
  
• A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies. Front Bioeng Biotechnol 8:688 (2020)
  Hinz, Steffen C.; Elter, Adrian; Rammo, Oliver; Schwämmle, Achim; Ali, Ataurehman; Zielonka, Stefan; Herget, Thomas & Kolmar, Harald
  
• Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity. Front Immunol 12, 715719 (2021)
  Elter, Adrian; Yanakieva, Desislava; Fiebig, David; Hallstein, Kerstin; Becker, Stefan; Betz, Ulrich & Kolmar, Harald