TF-PAR signaling in viral infections (02)

• Subject Area: Virology ; Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

This project explores how coagulation proteins regulate immune responses to viral infections through the PAR2 receptor. The focus is on the control of type I interferon signaling, which can drive autoimmune diseases when dysregulated. Using innovative mouse models and genetically modified immune cells, we aim to dissect these signaling mechanisms. We are particularly interested in the role of tissue factor (TF) and its interaction with the enzyme USP18. The goal is to identify novel strategies to modulate immune responses during acute and chronic viral infections.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Antje Beling; Professor Dr. Wolfram Ruf