Elucidating the interplay between coagulation and pH in modulating antitumor immunity (10)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

We preiously showed that myeloid cells, platelets, coagulation proteases and their receptors interact in the process of antigen uptake and antigen presentation thereby influencing the outcome of anti-tumor T cell responses and tumor growth control. In the third funding period, we will analyze the effects of pH on the expression and activity of coagulation proteases and how this can modulate antitumor immunity, through effects exerted on infiltrating macrophages and neutrophils. Within the CRC, we will elucidate the clinical implications of coagulation protease expression by macrophages, immunosuppressive neutrophils and dendritic cells in malignancy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Claudine Graf, Ph.D.; Dr. Hafsa Munir; Professor Dr. Wolfram Ruf, until 12/2025