Oxyfunctionalization through Photoinduced Oxygen Atom Transfer

• Applicant: Dr. Jola Pospech
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 401007518

The research project delineates the development of an organocatalytic oxyfunctionalization reaction through photomediated oxygen atom transfer. Relying on the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides, this approach will provide a chemical tool for the direct introduction of an alcohol functionality. The specific aim is to develop an efficient and practicable methodology that allows the direct chemical synthesis of oxygenated pharmacophors, biologically active compounds and xenobiotics that are otherwise accessed via enzymatic routes. Thus, elaborating a methodology for the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides would not only address a formidable challenge in organic synthesis, it would simultaneously provide a chemical equivalent to the mammalian arene and alkane monooxygenases.

• DFG Programme: Research Grants