Project Details
Projekt
Proteomics subtyping and circadian dynamics of PDACs to develop novel therapeutic strategies (P11)
Subject Area
Gastroenterology
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492
We will comprehensively study the proteome and phosphoproteome of genetically defined PDAC subtypes over time to achieve mechanistic insights into the cellular metabolism and signaling pathway networks driven by the circadian clock and different oncogenic mutations such as KrasG12D, KrasG12D/Trp53R172H, BrafV637E and Pik3caH1047R. The functional characterization of PDAC subtype specific candidate targets obtained from our proteomics/phosphoproteomics and circadian studies will allow us to pinpoint cancer markers and novel drug targets with the goal to develop subtype-specific chronotherapeutic treatment strategies for this devastating disease.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1321:
Modelling and Targeting Pancreatic Cancer
Applicant Institution
Technische Universität München (TUM)
