Die genetische Aufschlüsselung der Koordinationsmechanismen von Immunität und Stoffwechsel

• Antragstellerin: Professorin Dr. Mirka Uhlirova
• Fachliche Zuordnung: Allgemeine Genetik und funktionelle Genomforschung ; Entwicklungsbiologie
• Förderung: Förderung von 2018 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 404101084

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

In summary, our work highlights the cooperation of Multiplexin and Eater as an integral part of a homing mechanism that specifies and maintains hematopoietic sites in Drosophila. It underscores the importance of the physical interaction between the cell and its niche. On the contrary, our data do not support the notion that the formation of the de-novo hematopoietic site on the fat body surface depends on the tissue metabolic status nor sensory neurons and their activity as shown for sessile hematopoietic pockets. With the mounting interest in mechanistic aspects of hematopoietic progenitor-niche interactions in development, homeostasis, and disease and considering the evolutionary conservation of the identified interaction partners, we believe that our findings are significant, relevant and attractive to a broad research community.

Projektbezogene Publikationen (Auswahl)

• Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine. Cell Reports, 27(10), 3019-3033.e5.
  Mundorf, Juliane; Donohoe, Colin D.; McClure, Colin D.; Southall, Tony D. & Uhlirova, Mirka
  
• JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress. eLife, 8 (2019, 2, 8).
  Cosolo, Andrea; Jaiswal, Janhvi; Csordás, Gábor; Grass, Isabelle; Uhlirova, Mirka & Classen, Anne-Kathrin
  
• A Drosophila model to study retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8. Disease Models & Mechanisms, 13(6).
  Stanković, Dimitrije; Claudius, Ann-Katrin; Schertel, Thomas; Bresser, Tina & Uhlirova, Mirka
  
• Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments. eLife, 9 (2020, 10, 7).
  Csordás, Gábor; Grawe, Ferdinand & Uhlirova, Mirka
  
• Ecd promotes U5 snRNP maturation and Prp8 stability. Nucleic Acids Research, 49(3), 1688-1707.
  Erkelenz, Steffen; Stanković, Dimitrije; Mundorf, Juliane; Bresser, Tina; Claudius, Ann-Katrin; Boehm, Volker; Gehring, Niels H & Uhlirova, Mirka