Molecular function and downstream signaling of human and rodent P2X7 receptors (A15)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717

Blockade of the pro-inflammatory P2X7 receptor has beneficial effects in various rodent disease models but P2X7 antagonists have so far failed in clinical studies. Using in situ cross-linking and mass spectrometry we have identified a range of potential interactors. In the final funding period, we will continue to identify and validate extra- and intracellular P2X7 interactors and investigate to which extend murine P2X7 function and signaling is comparable to the human situation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1328: Adenine Nucleotides in Immunity and Inflammation
• Applicant Institution: Universität Hamburg
• Project Head: Professorin Dr. Annette Nicke