Inflammatory pathways in subtypes of intestinal cancer (P12)

• Subject Area: Gastroenterology ; Biochemistry
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 360372040

The molecular and cellular mechanisms that drive colon tumour progression and treatment resistance are not completely understood. In this project, we will decipher the communication networks between cancer cells, their microenvironment and the immune system in tissues. We will integrate cell type-specific proteomics with transcriptional activities and multiplexed (phospho)protein tissue imaging. We will create cell communication networks that reflect the molecular interplay of disease and validate their impact on immunosuppression and a robust anti-tumour immune response using genetic loss and gain of function studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1335: Aberrant Immune Signals in Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Felix Meissner; Professor Dr. Dieter Saur