Full Mechanical and Extra Cellular Matrix Profile of the Cancerous Liver during Tumor Progression and after Treatment with Novel theranostic XTEN Fusion Proteins (B08)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 372486779

The tumor surrounding extracellular matrix (ECM) has gained significant interest as an organizing principle of cancer formation and treatment response. Thus, we are investigating the mechanical and biological properties of liver tumors in murine and translational rabbit tumor models using multiparametric MRI and MR elastography. The ultimate goal is to develop non-invasive imaging biomarkers for the characterization of individual biological processes and compositions of the tumoral ECM and to design targeted ECM-activated fusion proteins for liver cancer treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1340: In vivo Visualization of Extracellular Matrix Pathology „Matrix in Vision“
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Jing Guo, Ph.D.; Privatdozentin Dr. Lynn Jeanette Savic, since 7/2022; Professor Dr. Eyk Schellenberger