A combined perturbation and modelling approach to understand and modulate the interactions between brain oscillations underlying memory consolidation in human NREM sleep (B03)

• Subject Area: Experimental and Theoretical Network Neuroscience ; Human Cognitive and Systems Neuroscience
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 327654276

We combine experimental work in human subjects with computational modelling of neurophysiological events, which correlate with and possibly underlie sleep-dependent memory consolidation in humans. Our main goals are to mechanistically understand the spatiotemporal patterns of slow oscillations, δ-waves, spindle, and sharp-wave ripple activity, to infer mechanisms of spatially distributed systems memory consolidation underlying the observed spatiotemporal patterns, to mechanistically understand and predict the impact of transcranial current stimulation on these oscillatory events, and to design efficient stimulation protocols for manipulating those patterns.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems
• Applicant Institution: Humboldt-Universität zu Berlin
• Project Heads: Professorin Dr. Agnes Flöel; Professor Dr. Klaus Obermayer; Professorin Dr. Petra Ritter, since 7/2022