Project Details
Projekt
Contextual modulation of spatial memory consolidation (B05)
Subject Area
Human Cognitive and Systems Neuroscience
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 327654276
The proposed project investigates contextual factors that may determine the relative contributions of hippocampus and neocortex within networks for spatial memory consolidation. Our central hypothesis is that availability of previous spatial knowledge critically determines hippocampal-neocortical interactions during systems consolidation. In four work packages (WPs), we will combine electrophysiological, pharmacological, imaging and lesion approaches in human patients and normal human subjects. In WP 1, we will study schema effects on ripples recorded from the human medial temporal lobe and neocortex. In WP 2, we will study whether early memory consolidation of schema-congruent and -incongruent information show a differential susceptibility to transient modulation of hippocampal activity with the anesthetic propofol. In WP3, we will study how contextual information modifies consolidation of spatial information acquired during free navigation. In WP 4, we will study how the availability of remote spatial memory facilitates consolidation of spatial memoranda independently from the hippocampus.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1315:
Mechanisms and disturbances in memory consolidation: From synapses to systems
Applicant Institution
Humboldt-Universität zu Berlin
