Burst-Feuern im Präsubikulum und die visuelle Verankerung vestibulärer Signale
Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Zusammenfassung der Projektergebnisse
Our grant ‘Burst’ focused on the rat subiculum. The key findings were the following: The subiculum is the major output structure of the hippocampal formation and is involved in learning and memory as well as in spatial navigation. Little was known about how the cellular diversity of subicular neurons relates to function. Previously, in vitro studies have identified distinct bursting patterns in subiculum. Here, we asked how burst firing is related to spatial coding in vivo. Using juxtacellular recordings in freely moving male rats, we analyzed the bursting behavior of 102 subicular principal neurons and distinguished two populations, i.e. sparsely bursting (ca. 80%) and dominantly bursting neurons (ca. 20%). The distinct burst firing patterns were related functional differences: the activity of sparsely bursting cells showed a stronger spatial modulation than the activity of dominantly bursting neurons. In most sparsely bursting cells – bursts defined sharper firing fields and carried more spatial information than isolated spikes. We conclude that burst firing is functionally relevant to subicular spatially tuned neurons, possibly by serving as a mechanism to transmit spatial information to downstream structures.
Projektbezogene Publikationen (Auswahl)
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Single or Double Patch-Clamp Recordings In Ex Vivo Slice Preparation: Functional Connectivity, Synapse Dynamics, and Optogenetics. Methods in Molecular Biology, 285-309. Springer US.
Simonnet, Jean; Richevaux, Louis & Fricker, Desdemona
