The dynamics of neuronal population signalling during the temporal flow of perceptual events.
Final Report Abstract
When we walk along a busy street against the flow of people and try to find someone we have arranged to meet, we face a world of dynamically changing visual inputs. Simultaneously, we must navigate around street furniture and people we do not want to meet whilst also scanning faces to achieve recognition of the person we seek. These temporal dynamics together with the need to integrate information encoded across different visual cues and areas are one of the next major challenges for systems neuroscience. My Heisenberg research programme investigated how neurons in the primate brain interact dynamically to shape such perceptual decision-making processes in the primate brain, employing neurophysiological recordings, high resolution MRI, and detailed analyses of the key neuroanatomical and functional neuronal circuitry across visual and parietal cortex. For project 1, the DFG Sachbeihilfe, we could show how signalling dynamic affects perceptual choice signals and perceptual stability for 3D-motion. We could also decode from neuronal signalling patterns across trials the cognitive strategy of the monkeys for future, upcoming choices. Employing neurocomputational approaches, we showed that there are fundamentally different processes for motion and 3D depth judgements. We also characterised the underlying functional and structural connectivity between V5/MT and sensorimotor area LIP in parietal cortex and their interactions. In the wider Heisenberg-Programme, we developed a set-up for structural and functional high-resolution MRI at 7T with Rhesus macaques and for focussed ultrasound stimulation. Here a major result is the demonstration of the correct subdivision of a primate cortical area with non-invasive diffusion MRI. We are currently translating this method to ADHD patients to determine precise brain stimulation targets in individuals.
Publications
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Developmental trajectory of social influence integration into perceptual decisions in children. Proceedings of the National Academy of Sciences, 116(7), 2713-2722.
Large, Imogen; Pellicano, Elizabeth; Mojzisch, Andreas & Krug, Kristine
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Interneuronal correlations at longer time scales predict decision signals for bistable structure-from-motion perception. Scientific Reports, 9(1).
Wasmuht, D. F.; Parker, A. J. & Krug, K.
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Offline impact of transcranial focused ultrasound on cortical activation in primates. ELife, 8.
Verhagen, Lennart; Gallea, Cécile; Folloni, Davide; Constans, Charlotte; Jensen, Daria EA; Ahnine, Harry; Roumazeilles, Léa; Santin, Mathieu; Ahmed, Bashir; Lehericy, Stéphane; Klein-Flügge, Miriam C; Krug, Kristine; Mars, Rogier B; Rushworth, Matthew FS; Pouget, Pierre; Aubry, Jean-François & Sallet, Jerome
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Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex. eLife, 8.
Bridge, Holly; Bell, Andrew H.; Ainsworth, Matthew; Sallet, Jerome; Premereur, Elsie; Ahmed, Bashir; Mitchell, Anna S.; Schüffelgen, Urs; Buckley, Mark; Tendler, Benjamin C.; Miller, Karla L.; Mars, Rogier B.; Parker, Andrew J. & Krug, Kristine
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Behavioral flexibility is associated with changes in structure and function distributed across a frontal cortical network in macaques. PLOS Biology, 18(5), e3000605.
Sallet, Jérôme; Noonan, MaryAnn P.; Thomas, Adam; O’Reilly, Jill X.; Anderson, Jesper; Papageorgiou, Georgios K.; Neubert, Franz X.; Ahmed, Bashir; Smith, Jackson; Bell, Andrew H.; Buckley, Mark J.; Roumazeilles, Léa; Cuell, Steven; Walton, Mark E.; Krug, Kristine; Mars, Rogier B. & Rushworth, Matthew F. S.
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Coding Perceptual Decisions: From Single Units to Emergent Signaling Properties in Cortical Circuits. Annual Review of Vision Science, 6(1), 387-409.
Krug, Kristine
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Cross-species cortical alignment identifies different types of anatomical reorganization in the primate temporal lobe. eLife, 9.
Eichert, Nicole; Robinson, Emma C.; Bryant, Katherine L.; Jbabdi, Saad; Jenkinson, Mark; Li, Longchuan; Krug, Kristine; Watkins, Kate E. & Mars, Rogier B.
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Differences in Frontal Network Anatomy Across Primate Species. The Journal of Neuroscience, 40(10), 2094-2107.
Barrett, Rachel L. C.; Dawson, Matthew; Dyrby, Tim B.; Krug, Kristine; Ptito, Maurice; D.'Arceuil, Helen; Croxson, Paula L.; Johnson, Philippa J.; Howells, Henrietta; Forkel, Stephanie J.; Dell'Acqua, Flavio & Catani, Marco
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Distinct decision processes for 3D and motion visual stimuli in humans and macaques. Society for Neuroscience (SFN) Washington DC abstracts PSTR413.12
Rangotis R., Nowakowska S., Kakaei E., Akande A. & Krug K.
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On the cortical connectivity in the macaque brain: A comparison of diffusion tractography and histological tracing data. NeuroImage, 221, 117201.
Girard, Gabriel; Caminiti, Roberto; Battaglia-Mayer, Alexandra; St-Onge, Etienne; Ambrosen, Karen S.; Eskildsen, Simon F.; Krug, Kristine; Dyrby, Tim B.; Descoteaux, Maxime; Thiran, Jean-Philippe & Innocenti, Giorgio M.
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The effects of reward and social context on visual processing for perceptual decision-making. Current Opinion in Physiology, 16, 109-117.
Takagaki, Kentaroh & Krug, Kristine
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Validation of structural brain connectivity networks: The impact of scanning parameters. NeuroImage, 204, 116207.
Ambrosen, Karen S.; Eskildsen, Simon F.; Hinne, Max; Krug, Kristine; Lundell, Henrik; Schmidt, Mikkel N.; van Gerven, Marcel A.J.; Mørup, Morten & Dyrby, Tim B.
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Intra-Areal Visual Topography in Primate Brains Mapped with Probabilistic Tractography of Diffusion-Weighted Imaging. Cerebral Cortex, 32(12), 2555-2574.
Tang-Wright, K.; Smith, J. E. T.; Bridge, H.; Miller, K. L.; Dyrby, T. B.; Ahmed, B.; Reislev, N. L.; Sallet, J.; Parker, A. J. & Krug, K.
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Histological validation of the accuracy of diffusion tensor imaging for tracing fibre tracts in macaque extrastriate visual cortex
Sams D., Smith J., Gaillard C., Ahmed B. & Krug K.
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Linear decoding applied to V5/MT neuronal activity on past trials predicts current sensory choices. FENS Forum, Artikel S03- 489
Ben Hadj Hassen S., Gaillard C., Parker A. & Krug K.
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Neuronal population activity in macaque V5/MT reflects and predicts visual perceptual strategy. Society for Neuroscience San Diego abstracts 545.23
Gaillard C., Ben Hadj Hassen S., Parker A. & Krug K.
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Histological validation of diffusion MRI and tractography for tracing fibre tracts in macaque extrastriate visual cortex. SFN Washington DC abstracts PSTR150.14
Sams D. L. N., Smith J. E. T., Gaillard C., Bashir A., Bridge H., Dyrby T. B. & Krug K.
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Segregated divisions of macaque lateral intraparietal area (LIP) revealed by post-mortem diffusion-weighted imaging and tractography. SFN Washington DC abstracts R148.05
Wirsum M., Smith J. E., Dyrby T. B. & Krug K.
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Anatomical circuits for flexible spatial mapping by single neurons in posterior parietal cortex.
Ahmed, Bashir; Ko, Hee Kyoung; Rüsseler, Maria; Smith, Jackson E. T. & Krug, Kristine
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Distinct decision processes for 3D and motion stimuli in both humans and monkeys revealed by computational modelling. openRxiv.
Rangotis, Revan; Nowakowska, Sabina; Dayan, Peter; Parker, Andrew J.; Kakaei, Ehsan; Akande, Abibat & Krug, Kristine
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Pulvinar projections to dorsal and ventral subdivisions of area LIP in the macaque. SFN Chicago
Ziegler S., Ahmed B., Parker A. J. & Krug K.
