Reagents for spatiotemporal control over TRPM/TRPC function (P24)

• Subject Area: Pharmacy
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

In project P24 we will generate new chemical reagents with which to modulate and study native TRP channels. We will develop photoswitchable reagents for modulating TRP channels in their physiological contexts with high spatiotemporal precision, both using classical approaches (sterically demanding photoswitches on known pharmacophores) and developing a novel, general approach (biolocalisation photocontrol). We will also synthesise photoaffinity label derivatives of TRP modulators to characterise their binding sites, and provide ongoing synthetic support to the CRC. P24 therefore promotes the general discovery, development, characterisation and use of modulators for native TRP channels.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Oliver Thorn-Seshold