Loss of the MG-induced cellular defense mechanism leads to the development of diabetic complications (C07+)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

Aim is the identification of the sensors, mediators and effectors of the MG-induced defense response. Mouse endothelial cells will be preconditioned using MG and HG, followed by characterization via mRNASeq, (phospho-)proteome analysis and endothelial function assays. Next, the role of the previously identified effector Hsp70 will be studied in regard to MG-induced protein aggregation, also by using Hsp70-knockout mice. The last part will focus on the identification of potential biomarkers to help identify patients at high risk for the development of diabetic late complications.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Dr. Johanna Zemva