Effects of impaired glucocorticoid receptor function in hemorrhagic shock-induced lung injury with pre-existing cigarette smoke-induced chronic obstructive pulmonary disease (B07*)

• Subject Area: Anaesthesiology ; Endocrinology, Diabetology, Metabolism
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251293561

When mice receive intensive care treatment, we found that a lack of GR dimerization (GRdim) increases mortality, aggravates hypotension, and further impairs lung function after challenge with lipopolysaccharides. Therefore, B07 N hypothesizes that lung injury and systemic inflammation after hemorrhagic shock are exacerbated in GRdim mice, which is further promoted by pre-traumatic cigarette smoke exposure-induced COPD. We expect that glucocorticoid (GC) treatment improves lung function and reduces inflammation through synergistic gene induction, which is promoted by inflammatory- and anti-inflammatory-acting signaling pathways dependent on GRdim in alternative macrophages.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1149: Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma
• Applicant Institution: Universität Ulm
• Project Heads: Privatdozentin Dr. Sabine Vettorazzi; Privatdozent Dr. Martin Wepler, until 12/2021