Role of prolyl-hydroxylase domain enzyme inhibitors in chronic renal inflammation (B05)

• Subject Area: Nephrology ; Rheumatology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Inhibition of prolyl hydroxylase domain enzymes (PHDi) protects mice in a model of chronic tubulointerstitial inflammasome-dependent kidney disease. PHDi-mediated protection required the presence of mononuclear phagocytes. Moreover, PHDi blocked caspase-1-dependent IL-1β release in mononuclear phagocytes. In order to test whether PHDi in mononuclear phagocytes ameliorates chronic nephritis we will characterize and analyze the contribution of subsets of mononuclear phagocytes in the pathogenesis of chronic inflammatory kidney diseases and their role in PHDi-mediated protection. Moreover, we will decipher how PHDi-treatment impairs IL-1β release in mononuclear phagocytes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Jonathan Jantsch; Professor Dr. Carsten Willam