Promoting renoprotection by unravelling the roles of renal oxygenation, energy metabolism and inflammation by physiometabolic magnetic resonance (B04)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology ; Anatomy and Physiology ; Medical Physics, Biomedical Technology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

Current treatments targeting acute kidney injury (AKI) and chronic kidney disease (CKD) are sparse due to the complexity of AKI pathophysiology and its progression to CKD. Renal tissue hypoperfusion, hypoxia, altered high energy metabolism and inflammation are tightly entangled. In this project, we will study the contributions and cause-effect relationships of hypoperfusion, hypoxia, energy metabolism and inflammation in AKI of various origins. These processes will be examined with an integrated multi-modality approach (MR-PHYSIOL-NIRS): magnetic resonance (1H, 19F, 31P MR), physiological readouts (PHYSIOL) and near infrared spectroscopy (NIRS). Our approach bridges physiometabolic MR in rodents with translational research leading to clinical studies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Major Instrumentation: CryoProbe
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Thoralf Niendorf, Ph.D.; Dr. Erdmann Seeliger