Co-transcriptional repair and transcriptional bypass of bulky DNA adducts (04)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839

The goal of this project is to understand the consequences of DNA lesions within a transcribed gene for the activity of the affected gene. To this end, we will incorporate a range of physiologically rele-vant DNA adducts at selected positions into a transcription template and investigate the efficiencies and accuracies of transcriptional bypass of these lesions in cells. In addition, we will address the modes of recognition of structurally distinct DNA lesions in transcribed DNA in order to identify the determinants for detection and removal of damaged nucleotides by the two major branches of the human nucleotide excision repair pathway.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1361: Regulation of DNA Repair and Genome Stability
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professor Dr. Andriy Khobta