Structural mechanism of MRN-ATM in DNA double-strand break signalling and processing (18)

• Subject Area: Structural Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839

This project aims at elucidating how DNA double-strand breaks are detected, signalled and processed by the Mre11-Rad50-Nbs1-ATM axis. To achieve this, we will use a combination of cryo-electron microscopy, bio-chemistry and cell-based studies. In particular, we will functionally and structurally dissect catalytic and scaffolding roles of MRN in order to provide molecular mechanisms for its poorly understood, pleiotropic func-tions in double-strand break repair and chromatin architecture.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1361: Regulation of DNA Repair and Genome Stability
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professor Dr. Karl-Peter Hopfner