Effects of microplastic interactions at the cellular level (A05)

• Subject Area: Biological Process Engineering ; Biomaterials
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 391977956

A05 investigates the effects of MP on cells and microtissues. While work in the 1st funding period (fp) focused mainly on single cells, in the 2nd fp this will shift to increasingly complex multicellular systems. Epithelial tissue (mimetics) and macrophages will be hierarchically organized and polarized (transwell cultures, spheroids). The experiments using primary cells of the model organisms established in CRC 1357 will be expanded and related to the effects observed in the respective organism. Thus, in the 2nd fp it is envisioned to increasingly close the gap between cellular and organismic response.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1357: MICROPLASTICS - Understanding the mechanisms and processes of biological effects, transport and formation: From model to complex systems as a basis for new solutions
• Applicant Institution: Universität Bayreuth
• Project Heads: Professorin Dr. Ruth Freitag; Professor Dr. Thomas Scheibel