Enzymatic degradation of synthetic polymers (C03)

• Subject Area: Biochemistry ; Structural Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 391977956

C03 focuses within the CRC 1357 on the degradation of microplastic (MP) through direct interaction with enzymes. A series of PET-degrading hydrolases show the potential of natural enzymes to degrade synthetic polymers. Degradation rates and selectivity of the enzymes can be tailored to related polymer species through rational design and directed evolution. The aim is to better understand and optimise the interaction of the enzymes with different polymer surfaces as well as the specific substrate recognition. Enzymes developed in this way can form the basis for large-scale biorecycling or the degradation of MP from PET and other aromatic polyesters in technical systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1357: MICROPLASTICS - Understanding the mechanisms and processes of biological effects, transport and formation: From model to complex systems as a basis for new solutions
• Applicant Institution: Universität Bayreuth
• Project Heads: Professorin Dr. Birte Höcker; Professor Dr. Matthias Ullmann, until 12/2022