Project Details
Projekt
Integrin subtype-specific organization and force transduction (A12)
Subject Area
Cell Biology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833
This project will investigate how distinct cell adhesion interfaces sense mechanochemical signals at the plasma membrane and transmit them to the nuclear envelope to modulate nuclear mechanotransduction. Experiments will employ various molecular force-sensing technologies, single-cell transcriptomics and real-time imaging of transcriptional kinetics to uncover communication principles between plasma membrane and the nucleus and assess the impact of this communication on cell state regulation.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Carsten Grashoff; Yekaterina Miroshnikova, Ph.D., since 1/2026
