Mechanisms of response and resistance to glioma-specific T-Cells (B01)

• Subject Area: Hematology, Oncology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

Based on work in the first funding period, we will specifically study mechanisms of resistance to therapies employing glioma-specific T cells. A focus will be on strategies to enhance T cell homing and to overcome T cell dysfunction in the glioblastoma microenvironment leveraging recently developed tools and knowledge from experimental glioma models employed. Furthermore, the analysis of post-treatment human glioma tissue from clinical trials and defined transgenic T cells recognizing glioma antigens allows testing hypotheses on determinants of metabolic, genetic, and exogenous factors defining T cell states in the glioblastoma microenvironment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Theresa Bunse; Professor Dr. Michael Platten