Molecular signatures underlying pathological gut-liver crosstalk and liver regeneration (A04)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology ; Analytical Chemistry ; Anatomy and Physiology ; Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

The portal vein is an essential compartment of the gut-liver axis and the molecular composition of portal vein blood can provide new insights into gut-liver crosstalk. Project A04 studies biomarkers and potential novel mediators of a pathological gut-liver crosstalk by analysing portal vein blood from patients with portal hypertension using mass spectrometry and molecular studies. Also, A04 studies blood biomarkers, molecular radiologic imaging markers and a predictive model for partial liver regeneration after portal vein embolisation in patients. Combined, this will reveal molecular signatures underlying pathological gut-liver crosstalk and liver regeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Dr. Emona Barzakova, since 7/2023; Professor Dr. Joachim Jankowski; Dr. Heidi Noels, Ph.D.