Consequences of bile-salt signalling for liver regeneration and pathophysiology (A07)

• Subject Area: Gastroenterology ; General and Visceral Surgery
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Signalling via host- and gut microbe-derived bile salts is involved in liver regeneration after partial hepatectomy. Cholestatic sequela impair the regenerative process and cause significant mortality in patients with perihilar cholangiocarcinoma, despite pre-operative biliary drainage. Project A07 studies how the interplay between cholestasis and drainage-related infections affects liver regeneration in post-cholestatic patients and defines underlying principles in mice. The combined approaches will reveal their reciprocal impact on regrowth of the post-cholestatic liver, and involved gut-liver mediators.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Steven Olde Damink, Ph.D.; Frank G. Schaap, Ph.D.