Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions (B03)

• Subject Area: Dermatology ; Immunology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931

This project will be based on insights of the last funding period on B cell development along the collagen VII-laminin-332-integrin axis in secondary lymphoid organs. The functional implications of collagen deficiency for B cell development towards an autoimmune-associated phenotype will be further mechanistically interrogated. Given the demonstration of autoantibody-driven autoimmunity as a driver of advanced disease in dystrophic epidermolysis bullosa (DEB), B03 will also evaluate proteasome inhibition or neonatal Fc receptor antagonism as a therapeutic approach to control autoimmune- and inflammation-driven organ damage in DEB mice.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1160: Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Privatdozentin Dr. Dimitra Kiritsi; Dr. Alexander Nyström